Disease variants of human &#916;<sup>1</sup>-pyrroline-5-carboxylate reductase 2 (PYCR2).

Patel, Sagar M; Seravalli, Javier; Liang, Xinwen; Tanner, John J; Becker, Donald F

Disease variants of human Δ¹-pyrroline-5-carboxylate reductase 2 (PYCR2).

Patel, Sagar M; Seravalli, Javier; Liang, Xinwen; Tanner, John J; Becker, Donald F.

Afiliación

Patel SM; Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Seravalli J; Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Liang X; Department of Pediatrics, Penn State College of Medicine, Hershey, PA, 17033, USA.
Tanner JJ; Departments of Biochemistry and Chemistry, University of Missouri, Columbia, MO, 65211, USA.
Becker DF; Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA. Electronic address: dbecker3@unl.edu.

Arch Biochem Biophys ; 703: 108852, 2021 05 30.

Article en En | MEDLINE | ID: mdl-33771508

Asunto(s)

Enfermedad/genética; Mutación; Pirrolina Carboxilato Reductasas/genética; Estabilidad de Enzimas; Humanos; Cinética; Estructura Secundaria de Proteína; Pirrolina Carboxilato Reductasas/química; Pirrolina Carboxilato Reductasas/metabolismo; Temperatura

Palabras clave

Circular dichroism; Product inhibition kinetics; Proline biosynthesis; Protein thermostability; Steady-state kinetics; Substrate-binding order; Δ(1)-pyrroline-5-carboxylate reductase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirrolina Carboxilato Reductasas / Enfermedad / Mutación Límite: Humans Idioma: En Revista: Arch Biochem Biophys Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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