TBK1 recruitment to STING activates both IRF3 and NF-&#954;B that mediate immune defense against tumors and viral infections.

Yum, Seoyun; Li, Minghao; Fang, Yan; Chen, Zhijian J

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections.

Yum, Seoyun; Li, Minghao; Fang, Yan; Chen, Zhijian J.

Afiliación

Yum S; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148.
Li M; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148.
Fang Y; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148.
Chen ZJ; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148.

Proc Natl Acad Sci U S A ; 118(14)2021 04 06.

Article en En | MEDLINE | ID: mdl-33785602

Asunto(s)

Herpes Simple/inmunología; Proteínas de la Membrana/metabolismo; Neoplasias/inmunología; Proteínas Serina-Treonina Quinasas/metabolismo; Animales; Autofagia; Línea Celular Tumoral; Células Cultivadas; Factor 3 Regulador del Interferón/metabolismo; Interferón Tipo I/metabolismo; Masculino; Proteínas de la Membrana/genética; Ratones; Ratones Endogámicos C57BL; Mutación Missense; FN-kappa B/metabolismo

Palabras clave

NF-κB; STING; TBK1; cGAS; interferon

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / Herpes Simple / Proteínas de la Membrana / Neoplasias Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article

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