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Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches.
Pievani, Alice; Savoldelli, Roberto; Poelchen, Juliane; Mattioli, Elisa; Anselmi, Giorgio; Girardot, Alice; Utikal, Jochen; Bourdely, Pierre; Serafini, Marta; Guermonprez, Pierre.
Afiliación
  • Pievani A; Department of Pediatrics, M. Tettamanti Research Center, University of Milano-Bicocca, Monza, Italy.
  • Savoldelli R; The Peter Gorer Department of Immunobiology, Centre for Inflammation Biology and Cancer Immunology, School of Immunology & Microbial Sciences, King's College London, London, United Kingdom.
  • Poelchen J; Cancer Research UK King's Health Partner Cancer Centre, King's College London, London, United Kingdom.
  • Mattioli E; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Anselmi G; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
  • Girardot A; The Peter Gorer Department of Immunobiology, Centre for Inflammation Biology and Cancer Immunology, School of Immunology & Microbial Sciences, King's College London, London, United Kingdom.
  • Utikal J; Cancer Research UK King's Health Partner Cancer Centre, King's College London, London, United Kingdom.
  • Bourdely P; MRC Molecular Hematology Unit, Radcliffe Department of Medicine, Medical Research Council, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
  • Serafini M; Centre for Inflammation Research, CNRS ERL8252, INSERM1149, Hopital Bichat, Université de Paris, Paris, France.
  • Guermonprez P; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Front Immunol ; 12: 631279, 2021.
Article en En | MEDLINE | ID: mdl-33790904
Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance, and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both in vitro and in vivo.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células del Estroma / Ingeniería de Tejidos / Nicho de Células Madre / Células Madre Mesenquimatosas Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células del Estroma / Ingeniería de Tejidos / Nicho de Células Madre / Células Madre Mesenquimatosas Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Italia