Endurance exercise training suppresses Parkinson disease-induced overexpression of apoptotic mediators in the heart.
NeuroRehabilitation
; 48(3): 315-320, 2021.
Article
en En
| MEDLINE
| ID: mdl-33814475
ABSTRACT
BACKGROUNDWe have shown elevated levels of p53 and active caspase-3 in the heart with Parkinson disease (PD). The main aim of this study is to examine the effect of treadmill training on the cardiac expression of p53 and active caspase-3 in the mouse with induced Parkinsonism. METHODS:
Thirty randomly selected normal albino mice were equally divided into the following 3 groups sedentary control (SC), sedentary Parkinson diseased (SPD), and exercised Parkinson diseased (EPD). 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid (MPTP/p) were used to induce chronic Parkinson disease in the SPD and EPD animals. The expression of p53 and active caspase-3 was investigated, using immunohistochemistry, in the heart in each animal group.RESULTS:
Both p53 and active caspase-3 expression was significantly (p valueâ<â0.05) reduced in the PD heart following endurance exercise training.CONCLUSION:
Our present data suggest that chronic exercise training reduced PD-induced upregulation of p53 and active caspase-3 in the heart. Thus, our study suggests that inhibiting p53 and/or active caspase-3 may be considered as a therapeutic approach to ameliorate PD cardiomyopathy.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Condicionamiento Físico Animal
/
Apoptosis
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Intoxicación por MPTP
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Miocardio
Límite:
Animals
Idioma:
En
Revista:
NeuroRehabilitation
Asunto de la revista:
NEUROLOGIA
/
REABILITACAO
Año:
2021
Tipo del documento:
Article
País de afiliación:
Jordania