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Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
Gaziano, Liam; Giambartolomei, Claudia; Pereira, Alexandre C; Gaulton, Anna; Posner, Daniel C; Swanson, Sonja A; Ho, Yuk-Lam; Iyengar, Sudha K; Kosik, Nicole M; Vujkovic, Marijana; Gagnon, David R; Bento, A Patrícia; Barrio-Hernandez, Inigo; Rönnblom, Lars; Hagberg, Niklas; Lundtoft, Christian; Langenberg, Claudia; Pietzner, Maik; Valentine, Dennis; Gustincich, Stefano; Tartaglia, Gian Gaetano; Allara, Elias; Surendran, Praveen; Burgess, Stephen; Zhao, Jing Hua; Peters, James E; Prins, Bram P; Angelantonio, Emanuele Di; Devineni, Poornima; Shi, Yunling; Lynch, Kristine E; DuVall, Scott L; Garcon, Helene; Thomann, Lauren O; Zhou, Jin J; Gorman, Bryan R; Huffman, Jennifer E; O'Donnell, Christopher J; Tsao, Philip S; Beckham, Jean C; Pyarajan, Saiju; Muralidhar, Sumitra; Huang, Grant D; Ramoni, Rachel; Beltrao, Pedro; Danesh, John; Hung, Adriana M; Chang, Kyong-Mi; Sun, Yan V; Joseph, Jacob.
Afiliación
  • Gaziano L; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Giambartolomei C; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Pereira AC; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy.
  • Gaulton A; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Posner DC; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.
  • Swanson SA; Genetics Department, Harvard Medical School, Harvard University, Boston, MA, USA.
  • Ho YL; Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Iyengar SK; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Kosik NM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Vujkovic M; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Gagnon DR; Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
  • Bento AP; Department of Population and Quantitative Health Sciences, Case Western Reserve University and Louis Stoke, Cleveland VA, Cleveland, OH, USA.
  • Barrio-Hernandez I; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Rönnblom L; The Corporal Michael J. Crescenz VA Medical Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Hagberg N; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Lundtoft C; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Langenberg C; Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
  • Pietzner M; Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Valentine D; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Gustincich S; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Tartaglia GG; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Allara E; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Surendran P; Berlin Institute of Health, Charité University Medicine Berlin, Berlin, Germany.
  • Burgess S; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Zhao JH; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Peters JE; Institute of Health Informatics, University College London, London, UK.
  • Prins BP; Health Data Research, University College London, London, UK.
  • Angelantonio ED; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy.
  • Devineni P; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy.
  • Shi Y; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Lynch KE; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • DuVall SL; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
  • Garcon H; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
  • Thomann LO; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Zhou JJ; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Gorman BR; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
  • Huffman JE; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • O'Donnell CJ; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
  • Tsao PS; Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College, London, UK.
  • Beckham JC; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Pyarajan S; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
  • Muralidhar S; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Huang GD; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
  • Ramoni R; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
  • Beltrao P; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
  • Danesh J; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.
  • Hung AM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Chang KM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Sun YV; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.
  • Joseph J; Department of Internal Medicine, Epidemiology, University of Utah, Salt Lake City, UT, USA.
Nat Med ; 27(4): 668-676, 2021 04.
Article en En | MEDLINE | ID: mdl-33837377
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Análisis de la Aleatorización Mendeliana / Reposicionamiento de Medicamentos / SARS-CoV-2 / COVID-19 Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Análisis de la Aleatorización Mendeliana / Reposicionamiento de Medicamentos / SARS-CoV-2 / COVID-19 Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos