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Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease.
de Goede, Olivia M; Nachun, Daniel C; Ferraro, Nicole M; Gloudemans, Michael J; Rao, Abhiram S; Smail, Craig; Eulalio, Tiffany Y; Aguet, François; Ng, Bernard; Xu, Jishu; Barbeira, Alvaro N; Castel, Stephane E; Kim-Hellmuth, Sarah; Park, YoSon; Scott, Alexandra J; Strober, Benjamin J; Brown, Christopher D; Wen, Xiaoquan; Hall, Ira M; Battle, Alexis; Lappalainen, Tuuli; Im, Hae Kyung; Ardlie, Kristin G; Mostafavi, Sara; Quertermous, Thomas; Kirkegaard, Karla; Montgomery, Stephen B.
Afiliación
  • de Goede OM; Department of Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address: odegoede@stanford.edu.
  • Nachun DC; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Ferraro NM; Biomedical Informatics Training Program, Stanford University, Stanford, CA 94305, USA.
  • Gloudemans MJ; Biomedical Informatics Training Program, Stanford University, Stanford, CA 94305, USA.
  • Rao AS; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Smail C; Biomedical Informatics Training Program, Stanford University, Stanford, CA 94305, USA; Genomic Medicine Center, Children's Mercy Research Institute, Kansas City, MO 64108, USA.
  • Eulalio TY; Biomedical Informatics Training Program, Stanford University, Stanford, CA 94305, USA.
  • Aguet F; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Ng B; Department of Statistics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Centre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada.
  • Xu J; Rush Alzheimer's Disease Center, Rush University, Chicago, Illinois 60612, USA.
  • Barbeira AN; Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.
  • Castel SE; New York Genome Center, New York, NY 10013, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA.
  • Kim-Hellmuth S; New York Genome Center, New York, NY 10013, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital LMU Munich, Munich 80337, Germany.
  • Park Y; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.
  • Scott AJ; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Strober BJ; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Brown CD; Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.
  • Wen X; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Hall IM; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Battle A; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Lappalainen T; New York Genome Center, New York, NY 10013, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA.
  • Im HK; Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.
  • Ardlie KG; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Mostafavi S; Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA.
  • Quertermous T; Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA.
  • Kirkegaard K; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
  • Montgomery SB; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Department of Pathology, Stanford University, Stanford, CA 94305, USA. Electronic address: smontgom@stanford.edu.
Cell ; 184(10): 2633-2648.e19, 2021 05 13.
Article en En | MEDLINE | ID: mdl-33864768
ABSTRACT
Long non-coding RNA (lncRNA) genes have well-established and important impacts on molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a major challenge to identify the subset with disease or trait relevance. To systematically characterize these lncRNA genes, we used Genotype Tissue Expression (GTEx) project v8 genetic and multi-tissue transcriptomic data to profile the expression, genetic regulation, cellular contexts, and trait associations of 14,100 lncRNA genes across 49 tissues for 101 distinct complex genetic traits. Using these approaches, we identified 1,432 lncRNA gene-trait associations, 800 of which were not explained by stronger effects of neighboring protein-coding genes. This included associations between lncRNA quantitative trait loci and inflammatory bowel disease, type 1 and type 2 diabetes, and coronary artery disease, as well as rare variant associations to body mass index.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Población / Enfermedad / Herencia Multifactorial / Transcriptoma / ARN Largo no Codificante Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Población / Enfermedad / Herencia Multifactorial / Transcriptoma / ARN Largo no Codificante Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Año: 2021 Tipo del documento: Article