Comparison of the efficacy and safety of cuffed versus uncuffed endotracheal tubes for infants in the intensive care setting: a pilot, unblinded RCT.
Arch Dis Child Fetal Neonatal Ed
; 106(6): 614-620, 2021 Nov.
Article
en En
| MEDLINE
| ID: mdl-33879529
ABSTRACT
OBJECTIVE:
To study effectiveness and safety of cuffed versus uncuffed endotracheal tubes (ETTs) in small infants in the intensive care unit (ICU).DESIGN:
Pilot RCT.SETTING:
Neonatal and paediatric ICUs of children's hospital in Western Australia.PARTICIPANTS:
Seventy-six infants ≥35 weeks gestation and infants <3 months of age, ≥3 kg.INTERVENTIONS:
Patients randomly assigned to Microcuff cuffed or Portex uncuffed ETT. MAIN OUTCOMESMEASURES:
Primary outcome was achievement of optimal ETT leak in target range (10%-20%). Secondary outcomes included reintubations, ventilatory parameters, ventilatory complications, postextubation complications and long-term follow-up.RESULTS:
Success rate (achievement of mean leak in the range 10%-20%) was 13/42 (30.9%) in the cuffed ETT group and 6/34 (17.6%) in uncuffed ETT group (OR=2.09; 95% CI (0.71 to 6.08); p=0.28). Mean percentage time within target leak range in cuffed ETT group 28% (IQR 9-42) versus 15% (IQR 0-28) in uncuffed ETT group (p=0.01). There were less reintubations to optimise size in cuffed ETT group 0/40 versus 10/36 (p<0.001). No differences were found in gaseous exchange, ventilator parameters or postextubation complications. There were fewer episodes of atelectasis in cuffed ETT group 0/42 versus 4/34 (p=0.03). No patient had been diagnosed with subglottic stenosis at long-term follow-up.CONCLUSIONS:
There was no difference in the primary outcome, though percentage time spent in optimal leak range was significantly higher in cuffed ETT group. Cuffed ETTs reduced reintubations to optimise ETT size and episodes of atelectasis. Cuffed ETTs may be a feasible alternative to uncuffed ETTs in this group of patients. TRIAL REGISTRATION NUMBER ACTRN12615000081516.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Atelectasia Pulmonar
/
Diseño de Equipo
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Efectos Adversos a Largo Plazo
/
Intubación Intratraqueal
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
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Female
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Humans
/
Male
/
Newborn
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Arch Dis Child Fetal Neonatal Ed
Asunto de la revista:
PEDIATRIA
/
PERINATOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Australia