Single-cell molecular and developmental perspectives of sexually dimorphic circuits underlying innate social behaviors.
Curr Opin Neurobiol
; 68: 159-166, 2021 06.
Article
en En
| MEDLINE
| ID: mdl-33915498
ABSTRACT
While single-cell transcriptomics in the brain has uncovered a vast diversity of neural cell types in unprecedented detail, it is becoming increasingly urgent to address what exactly their functional roles are in the context of circuits and behavior. In this review, we discuss the molecular profiling of cell types in circuits underlying social behaviors in mice as a prominent case study. We first highlight key roles of molecularly identified sensory and downstream neurons involved in sexually dimorphic behaviors. We then propose future opportunities to define cell types using multimodal criteria, especially gene expression, physiology, as well as the developmental origin, to advance our understanding of these circuits.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Conducta Sexual Animal
/
Caracteres Sexuales
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Curr Opin Neurobiol
Asunto de la revista:
BIOLOGIA
/
NEUROLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
España