BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19.
Vaccines (Basel)
; 9(4)2021 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-33915773
ABSTRACT
BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge.
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Banco de datos:
MEDLINE
Idioma:
En
Revista:
Vaccines (Basel)
Año:
2021
Tipo del documento:
Article
País de afiliación:
China