Bactericidal urea crown ethers target phosphatidylethanolamine membrane lipids.
Org Biomol Chem
; 19(17): 3838-3843, 2021 05 05.
Article
en En
| MEDLINE
| ID: mdl-33949594
An increasing number of people are infected with antibiotic-resistant bacteria each year, sometimes with fatal consequences. In this manuscript, we report a novel urea-functionalized crown ether that can bind to the bacterial lipid phosphatidylethanolamine (PE), facilitate PE flip-flop and displays antibacterial activity against the Gram-positive bacterium Bacillus cereus with a minimum inhibitory concentration comparable to that of the known PE-targeting lantibiotic duramycin.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fosfatidiletanolaminas
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos