Vitamin D receptor activated by vitamin D administration alleviates Mycobacterium tuberculosis-induced bone destruction by inhibiting NF&#954;B-mediated aberrant osteoclastogenesis.

Deng, Jiezhong; Yang, Yusheng; He, Jinyue; Xie, Zhao; Luo, Fei; Xu, Jianzhong; Zhang, Zehua

Vitamin D receptor activated by vitamin D administration alleviates Mycobacterium tuberculosis-induced bone destruction by inhibiting NFκB-mediated aberrant osteoclastogenesis.

Deng, Jiezhong; Yang, Yusheng; He, Jinyue; Xie, Zhao; Luo, Fei; Xu, Jianzhong; Zhang, Zehua.

Afiliación

Deng J; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Yang Y; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
He J; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Xie Z; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Luo F; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Xu J; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Zhang Z; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

FASEB J ; 35(6): e21543, 2021 06.

Article en En | MEDLINE | ID: mdl-34046950

Asunto(s)

Macrófagos/efectos de los fármacos; Mycobacterium tuberculosis/patogenicidad; FN-kappa B/antagonistas & inhibidores; Osteólisis/prevención & control; Receptores de Calcitriol/metabolismo; Tuberculosis/complicaciones; Vitamina D/administración & dosificación; Animales; Macrófagos/metabolismo; Macrófagos/microbiología; Masculino; Ratones; Ratones Endogámicos C57BL; FN-kappa B/genética; FN-kappa B/metabolismo; Osteólisis/etiología; Osteólisis/metabolismo; Osteólisis/patología; Receptores de Calcitriol/genética; Tuberculosis/microbiología; Vitaminas/administración & dosificación

Palabras clave

Mycobacterium tuberculosis; VDR; osteoclastogenesis; vitamin D

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Osteólisis / Tuberculosis / Vitamina D / FN-kappa B / Receptores de Calcitriol / Macrófagos / Mycobacterium tuberculosis Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China

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