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Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans.
Baker, Suzanne L; Provost, Karine; Thomas, Wesley; Whitman, A J; Janabi, Mustafa; Schmidt, Mark E; Timmers, Maarten; Kolb, Hartmuth C; Rabinovici, Gil D; Jagust, William J.
Afiliación
  • Baker SL; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
  • Provost K; Memory and Aging Center, Department of Neurology, University of California, Berkeley, CA, USA.
  • Thomas W; Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.
  • Whitman AJ; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
  • Janabi M; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
  • Schmidt ME; Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
  • Timmers M; Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
  • Kolb HC; Neuroscience Biomarker Research, La Jolla, CA, USA.
  • Rabinovici GD; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
  • Jagust WJ; Memory and Aging Center, Department of Neurology, University of California, Berkeley, CA, USA.
J Cereb Blood Flow Metab ; 41(12): 3302-3313, 2021 12.
Article en En | MEDLINE | ID: mdl-34259071
ABSTRACT
The [18F]-JNJ-64326067-AAA ([18F]-JNJ-067) tau tracer was evaluated in healthy older controls (HCs), mild cognitive impairment (MCI), Alzheimer's disease (AD), and progressive supranuclear palsy (PSP) participants. Seventeen subjects (4 HCs, 5 MCIs, 5 ADs, and 3 PSPs) received a [11C]-PIB amyloid PET scan, and a tau [18F]-JNJ-067 PET scan 0-90 minutes post-injection. Only MCIs and ADs were amyloid positive. The simplified reference tissue model, Logan graphical analysis distribution volume ratio, and SUVR were evaluated for quantification. The [18F]-JNJ-067 tau signal relative to the reference region continued to increase to 90 min, indicating the tracer had not reached steady state. There was no significant difference in any bilateral ROIs for MCIs or PSPs relative to HCs; AD participants showed elevated tracer relative to controls in most cortical ROIs (P < 0.05). Only AD participants showed elevated retention in the entorhinal cortex. There was off-target signal in the putamen, pallidum, thalamus, midbrain, superior cerebellar gray, and white matter. [18F]-JNJ-067 significantly correlated (p < 0.05) with Mini-Mental State Exam in entorhinal cortex and temporal meta regions. There is clear binding of [18F]-JNJ-067 in AD participants. Lack of binding in HCs, MCIs and PSPs suggests [18F]-JNJ-067 may not bind to low levels of AD-related tau or 4 R tau.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Encéfalo / Radioisótopos de Flúor / Proteínas tau / Radiofármacos / Tomografía de Emisión de Positrones / Enfermedad de Alzheimer / Isoquinolinas Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Cereb Blood Flow Metab Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Encéfalo / Radioisótopos de Flúor / Proteínas tau / Radiofármacos / Tomografía de Emisión de Positrones / Enfermedad de Alzheimer / Isoquinolinas Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Cereb Blood Flow Metab Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos