Analysis of chromatid-break-repair detects a homologous recombination to non-homologous end-joining switch with increasing load of DNA double-strand breaks.

Murmann-Konda, Tamara; Soni, Aashish; Stuschke, Martin; Iliakis, George

Murmann-Konda, Tamara; Soni, Aashish; Stuschke, Martin; Iliakis, George.

Afiliación

Murmann-Konda T; Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Soni A; Division of Experimental Radiation Biology, Department of Radiation Therapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address: aashish.soni@uk-e
Stuschke M; Division of Experimental Radiation Biology, Department of Radiation Therapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, and German Cancer Research Center (DKFZ), Essen, Germany.
Iliakis G; Division of Experimental Radiation Biology, Department of Radiation Therapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address: georg.Iliakis@uk-

Mutat Res Genet Toxicol Environ Mutagen ; 867: 503372, 2021 Jul.

Article en En | MEDLINE | ID: mdl-34266628

Asunto(s)

Cromátides/genética; Reparación del ADN por Unión de Extremidades/genética; ADN/genética; Recombinación Homóloga/genética; Reparación del ADN por Recombinación/genética; Animales; Células CHO; Línea Celular; Cricetulus; Roturas del ADN de Doble Cadena; Reparación del ADN/genética; Fase G2/genética; Poli(ADP-Ribosa) Polimerasa-1/genética; Radiación Ionizante

Palabras clave

Classical non-homologous end joining (c-NHEJ); DNA Double Strand Breaks (DSB); DSB repair pathway choice; G(2) chromatid breaks (CHROMATID BREAKS); Homologous recombination (HR); Ionizing Radiation (IR); Premature chromosome condensation (PCC)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN / Cromátides / Reparación del ADN por Unión de Extremidades / Reparación del ADN por Recombinación / Recombinación Homóloga Límite: Animals Idioma: En Revista: Mutat Res Genet Toxicol Environ Mutagen Año: 2021 Tipo del documento: Article País de afiliación: Alemania

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