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Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors.
Tong, Yunsong; Florjancic, Alan S; Clark, Rick F; Lai, Chunqiu; Mastracchio, Anthony; Zhu, Gui-Dong; Smith, Morey L; Kovar, Peter J; Shaw, Bailin; Albert, Daniel H; Qiu, Wei; Longenecker, Kenton L; Liu, Xiaoqin; Olson, Amanda M; Osterling, Donald J; Tahir, Stephen K; Phillips, Darren C; Leverson, Joel D; Souers, Andrew J; Penning, Thomas D.
Afiliación
  • Tong Y; Drug Discovery Science & Technology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Florjancic AS; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Clark RF; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Lai C; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Mastracchio A; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Zhu GD; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Smith ML; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Kovar PJ; High Throughput Biology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Shaw B; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Albert DH; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Qiu W; Structural Biology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Longenecker KL; Structural Biology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Liu X; Pharmacology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Olson AM; Pharmacology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Osterling DJ; Pharmacology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Tahir SK; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Phillips DC; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Leverson JD; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Souers AJ; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Penning TD; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
ACS Med Chem Lett ; 12(7): 1108-1115, 2021 Jul 08.
Article en En | MEDLINE | ID: mdl-34267880
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos