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Human models for COVID-19 research.
Woodall, Maximillian N J; Masonou, Tereza; Case, Katie-Marie; Smith, Claire M.
Afiliación
  • Woodall MNJ; GOS Institute of Child Health, University College London, London, UK.
  • Masonou T; GOS Institute of Child Health, University College London, London, UK.
  • Case KM; GOS Institute of Child Health, University College London, London, UK.
  • Smith CM; GOS Institute of Child Health, University College London, London, UK.
J Physiol ; 599(18): 4255-4267, 2021 09.
Article en En | MEDLINE | ID: mdl-34287894
Currently, therapeutics for COVID-19 are limited. To overcome this, it is important that we use physiologically relevant models to reproduce the pathology of infection and evaluate the efficacy of antiviral drugs. Models of airway infection, including the use of a human infection challenge model or well-defined, disease relevant in vitro systems can help determine the key components that perpetuate the severity of the disease. Here, we briefly review the human models that are currently being used in COVID-19 research and drug development.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: COVID-19 Límite: Humans Idioma: En Revista: J Physiol Año: 2021 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: COVID-19 Límite: Humans Idioma: En Revista: J Physiol Año: 2021 Tipo del documento: Article