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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Hamilton, Matthew M; Mseeh, Faika; McAfoos, Timothy J; Leonard, Paul G; Reyna, Naphtali J; Harris, Angela L; Xu, Alan; Han, Michelle; Soth, Michael J; Czako, Barbara; Theroff, Jay P; Mandal, Pijus K; Burke, Jason P; Virgin-Downey, Brett; Petrocchi, Alessia; Pfaffinger, Dana; Rogers, Norma E; Parker, Connor A; Yu, Simon S; Jiang, Yongying; Krapp, Stephan; Lammens, Alfred; Trevitt, Graham; Tremblay, Martin R; Mikule, Keith; Wilcoxen, Keith; Cross, Jason B; Jones, Philip; Marszalek, Joseph R; Lewis, Richard T.
Afiliación
  • Hamilton MM; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Mseeh F; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • McAfoos TJ; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Leonard PG; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Reyna NJ; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Harris AL; TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Xu A; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Han M; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Soth MJ; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Czako B; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Theroff JP; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Mandal PK; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Burke JP; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Virgin-Downey B; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Petrocchi A; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Pfaffinger D; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Rogers NE; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Parker CA; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Yu SS; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Jiang Y; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Krapp S; Proteros Biostructures GmbH, Bunsenstr. 7a, D-82152 Martinsried, Germany.
  • Lammens A; Proteros Biostructures GmbH, Bunsenstr. 7a, D-82152 Martinsried, Germany.
  • Trevitt G; XenoGesis Ltd, BioCity Nottingham, Pennyfoot Street, Nottingham, Nottinghamshire NG1 1GF, U.K.
  • Tremblay MR; Tesaro Inc., 1000 Winter Street, Waltham, Massachusetts 02451 United States.
  • Mikule K; Tesaro Inc., 1000 Winter Street, Waltham, Massachusetts 02451 United States.
  • Wilcoxen K; Tesaro Inc., 1000 Winter Street, Waltham, Massachusetts 02451 United States.
  • Cross JB; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Jones P; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Marszalek JR; TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
  • Lewis RT; IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.
J Med Chem ; 64(15): 11302-11329, 2021 08 12.
Article en En | MEDLINE | ID: mdl-34292726
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenasa / Descubrimiento de Drogas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenasa / Descubrimiento de Drogas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos