Different voltage dependence of I<sub>CaL</sub> blockade in nonselective I<sub>Kr</sub> blockers causes their opposite effects on early afterdepolarization in drug-induced arrhythmia.

Kimura, Akira; Murakami, Shingo

Different voltage dependence of I_CaL blockade in nonselective I_Kr blockers causes their opposite effects on early afterdepolarization in drug-induced arrhythmia.

Kimura, Akira; Murakami, Shingo.

Afiliación

Kimura A; Department of Electrical, Electronic, and Communication Engineering, Faculty of Science and Engineering, Chuo University, Tokyo, Japan.
Murakami S; Department of Electrical, Electronic, and Communication Engineering, Faculty of Science and Engineering, Chuo University, Tokyo, Japan. Electronic address: murakami@elect.chuo-u.ac.jp.

J Pharmacol Sci ; 147(1): 95-103, 2021 Sep.

Article en En | MEDLINE | ID: mdl-34294379

Asunto(s)

Arritmias Cardíacas/inducido químicamente; Arritmias Cardíacas/fisiopatología; Potasio/metabolismo; Potenciales de Acción; Amiodarona/efectos adversos; Amiodarona/farmacocinética; Bepridil/efectos adversos; Bepridil/farmacocinética; Canales de Calcio Tipo L/metabolismo; Simulación por Computador; Ventrículos Cardíacos/efectos de los fármacos; Humanos; Potenciales de la Membrana/efectos de los fármacos; Modelos Teóricos; Miocitos Cardíacos; Terfenadina/efectos adversos; Terfenadina/farmacocinética

Palabras clave

Computer simulation; Drug-induced arrhythmia; Early afterdepolarization; I(CaL)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Arritmias Cardíacas / Potasio Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: J Pharmacol Sci Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Japón

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