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Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.
Kaiser, Rainer; Leunig, Alexander; Pekayvaz, Kami; Popp, Oliver; Joppich, Markus; Polewka, Vivien; Escaig, Raphael; Anjum, Afra; Hoffknecht, Marie-Louise; Gold, Christoph; Brambs, Sophia; Engel, Anouk; Stockhausen, Sven; Knottenberg, Viktoria; Titova, Anna; Haji, Mohamed; Scherer, Clemens; Muenchhoff, Maximilian; Hellmuth, Johannes C; Saar, Kathrin; Schubert, Benjamin; Hilgendorff, Anne; Schulz, Christian; Kääb, Stefan; Zimmer, Ralf; Hübner, Norbert; Massberg, Steffen; Mertins, Philipp; Nicolai, Leo; Stark, Konstantin.
Afiliación
  • Kaiser R; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Leunig A; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
  • Pekayvaz K; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, Ludwig-Maximilians University Munich, Munich, Germany.
  • Popp O; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Joppich M; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
  • Polewka V; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Escaig R; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
  • Anjum A; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, Ludwig-Maximilians University Munich, Munich, Germany.
  • Hoffknecht ML; Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany.
  • Gold C; DZHK, partner site Berlin, Berlin, Germany.
  • Brambs S; Department of Informatics, Ludwig-Maximilians University Munich, Munich, Germany.
  • Engel A; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Stockhausen S; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Knottenberg V; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Titova A; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Haji M; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Scherer C; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Muenchhoff M; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Hellmuth JC; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Saar K; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
  • Schubert B; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Hilgendorff A; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Schulz C; Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany.
  • Kääb S; DZHK, partner site Berlin, Berlin, Germany.
  • Zimmer R; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Germany.
  • Hübner N; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
  • Massberg S; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, Ludwig-Maximilians University Munich, Munich, Germany.
  • Mertins P; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, Ludwig-Maximilians University Munich, Munich, Germany.
  • Nicolai L; Max von Pettenkofer Institute and GeneCenter, Virology, Faculty of Medicine, Ludwig-Maximilians University, Munich, Germany.
  • Stark K; German Center for Infection Research, Partner Site Munich, Munich, Germany.
JCI Insight ; 6(18)2021 09 22.
Article en En | MEDLINE | ID: mdl-34403366
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trombosis / Interleucina-8 / SARS-CoV-2 / COVID-19 / Pulmón / Neutrófilos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: JCI Insight Año: 2021 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trombosis / Interleucina-8 / SARS-CoV-2 / COVID-19 / Pulmón / Neutrófilos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: JCI Insight Año: 2021 Tipo del documento: Article País de afiliación: Alemania