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Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity.
Azzimato, Valerio; Chen, Ping; Barreby, Emelie; Morgantini, Cecilia; Levi, Laura; Vankova, Ana; Jager, Jennifer; Sulen, André; Diotallevi, Marina; Shen, Joanne X; Miller, Anne; Ellis, Ewa; Rydén, Mikael; Näslund, Erik; Thorell, Anders; Lauschke, Volker M; Channon, Keith M; Crabtree, Mark J; Haschemi, Arvand; Craige, Siobhan M; Mori, Mattia; Spallotta, Francesco; Aouadi, Myriam.
Afiliación
  • Azzimato V; Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Institutet, Huddinge, Sweden. Electronic address: valerio.azzimato@ki.se.
  • Chen P; Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Barreby E; Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Morgantini C; Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Levi L; Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Vankova A; Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Jager J; Université Côte d'Azur, Inserm, Centre Méditerranéen de Médecine Moléculaire (C3M), Team « Cellular and Molecular Pathophysiology of Obesity and Diabetes,¼ Côte d'Azur, France.
  • Sulen A; Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Diotallevi M; BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Shen JX; Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden.
  • Miller A; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
  • Ellis E; Division of Transplantation Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
  • Rydén M; Department of Medicine (H7), Karolinska Institutet, Huddinge, Sweden.
  • Näslund E; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
  • Thorell A; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden.
  • Lauschke VM; Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
  • Channon KM; BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Crabtree MJ; BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Haschemi A; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
  • Craige SM; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia.
  • Mori M; Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, Siena, Italy.
  • Spallotta F; Institute for Systems Analysis and Computer Science "A. Ruberti," National Research Council (IASI - CNR), Rome, Italy.
  • Aouadi M; Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Institutet, Huddinge, Sweden. Electronic address: myriam.aouadi@ki.se.
Gastroenterology ; 161(6): 1982-1997.e11, 2021 12.
Article en En | MEDLINE | ID: mdl-34425095
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / MicroARNs / Factor 2 Relacionado con NF-E2 / Hígado Graso / Fumarato Hidratasa / Hígado / Macrófagos / Obesidad Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Gastroenterology Año: 2021 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / MicroARNs / Factor 2 Relacionado con NF-E2 / Hígado Graso / Fumarato Hidratasa / Hígado / Macrófagos / Obesidad Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Gastroenterology Año: 2021 Tipo del documento: Article