MiR-142-5p serves as a tumor suppressor in retinoblastoma cells by regulating MYCN.
Biochem Biophys Res Commun
; 574: 20-26, 2021 10 15.
Article
en En
| MEDLINE
| ID: mdl-34425282
ABSTRACT
Retinoblastoma is an intraocular malignant tumor and generally occurred in childhood. Here, we intended to appraise the functional influence of microRNA-142-5p (miR-142-5p) in retinoblastoma. MiR-142-5p was declined, and MYCN was upregulated in retinoblastoma tissues and cells. Moreover, miR-142-5p restricted cell proliferation, migration, invasion, and enhanced cell apoptosis in retinoblastoma cells. MYCN was adversely controlled by miR-142-5p. Besides, the inhibition of miR-142-5p-mediated effects on retinoblastoma progression were blocked by MYCN overexpression in retinoblastoma cells. This research illustrated that miR-142-5p restricted retinoblastoma progression via interacting with MYCN.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Retinoblastoma
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MicroARNs
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Proteína Proto-Oncogénica N-Myc
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2021
Tipo del documento:
Article