TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway.

Wang, Huiyuan; Zhong, Bo; Geng, Yan; Hao, Juanjuan; Jin, Qiaoyan; Zhang, Yang; Dong, Lijuan; Gao, Dan; Li, Jing; Hou, Wei

Wang, Huiyuan; Zhong, Bo; Geng, Yan; Hao, Juanjuan; Jin, Qiaoyan; Zhang, Yang; Dong, Lijuan; Gao, Dan; Li, Jing; Hou, Wei.

Afiliación

Wang H; Department of Pediatric, The Second Affiliated Hospital of Xi'an Jiaotong University, NO.157, Xiwu Road, Xi'an, 710004, Shaanxi, China.
Zhong B; Department of Pediatric, The Second Affiliated Hospital of Xi'an Jiaotong University, NO.157, Xiwu Road, Xi'an, 710004, Shaanxi, China.
Geng Y; Department of Pediatric, The Second Affiliated Hospital of Xi'an Jiaotong University, NO.157, Xiwu Road, Xi'an, 710004, Shaanxi, China.
Hao J; Department of Pediatric, The Second Affiliated Hospital of Xi'an Jiaotong University, NO.157, Xiwu Road, Xi'an, 710004, Shaanxi, China.
Jin Q; Department of Pediatric, The Second Affiliated Hospital of Xi'an Jiaotong University, NO.157, Xiwu Road, Xi'an, 710004, Shaanxi, China.
Zhang Y; Department of Pediatric, The Second Affiliated Hospital of Xi'an Jiaotong University, NO.157, Xiwu Road, Xi'an, 710004, Shaanxi, China.
Dong L; Department of Pediatric, The Second Affiliated Hospital of Xi'an Jiaotong University, NO.157, Xiwu Road, Xi'an, 710004, Shaanxi, China.
Gao D; Department of Pediatric, The Second Affiliated Hospital of Xi'an Jiaotong University, NO.157, Xiwu Road, Xi'an, 710004, Shaanxi, China.
Li J; Department of Pediatric, The Second Affiliated Hospital of Xi'an Jiaotong University, NO.157, Xiwu Road, Xi'an, 710004, Shaanxi, China.
Hou W; Department of Pediatric, The Second Affiliated Hospital of Xi'an Jiaotong University, NO.157, Xiwu Road, Xi'an, 710004, Shaanxi, China. houweiped@163.com.

Respir Res ; 22(1): 238, 2021 Aug 26.

Article en En | MEDLINE | ID: mdl-34446024

Asunto(s)

Becaplermina/toxicidad; Péptidos y Proteínas de Señalización Intracelular/biosíntesis; Músculo Liso/metabolismo; Miocitos del Músculo Liso/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Remodelación de las Vías Aéreas (Respiratorias)/efectos de los fármacos; Remodelación de las Vías Aéreas (Respiratorias)/fisiología; Animales; Células Cultivadas; Relación Dosis-Respuesta a Droga; Ratones; Ratones Endogámicos C57BL; Músculo Liso/efectos de los fármacos; Miocitos del Músculo Liso/efectos de los fármacos; Fenotipo; Inhibidores de las Quinasa Fosfoinosítidos-3/metabolismo; Proteínas Proto-Oncogénicas c-akt/antagonistas & inhibidores; Transducción de Señal/efectos de los fármacos; Transducción de Señal/fisiología; Tráquea/citología; Tráquea/efectos de los fármacos; Tráquea/metabolismo

Palabras clave

Airway smooth muscle cells (ASMCs); Childhood asthma; PI3K/Akt signaling pathway; Phenotype switching; TIPE2

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas / Miocitos del Músculo Liso / Péptidos y Proteínas de Señalización Intracelular / Proteínas Proto-Oncogénicas c-akt / Becaplermina / Músculo Liso Límite: Animals Idioma: En Revista: Respir Res Año: 2021 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google