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Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model.
Yang, Taihua; Poenisch, Marion; Khanal, Rajendra; Hu, Qingluan; Dai, Zhen; Li, Ruomeng; Song, Guangqi; Yuan, Qinggong; Yao, Qunyan; Shen, Xizhong; Taubert, Richard; Engel, Bastian; Jaeckel, Elmar; Vogel, Arndt; Falk, Christine S; Schambach, Axel; Gerovska, Daniela; Araúzo-Bravo, Marcos J; Vondran, Florian W R; Cantz, Tobias; Horscroft, Nigel; Balakrishnan, Asha; Chevessier, Frédéric; Ott, Michael; Sharma, Amar Deep.
Afiliación
  • Yang T; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Research Group Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany; Present address of TY, Department of Liver Surgery
  • Poenisch M; CureVac AG, Tübingen, Germany.
  • Khanal R; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Research Group Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany.
  • Hu Q; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Dai Z; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Research Group Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany.
  • Li R; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Research Group Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany.
  • Song G; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China.
  • Yuan Q; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Yao Q; Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China.
  • Shen X; Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China.
  • Taubert R; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Engel B; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Jaeckel E; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Vogel A; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Falk CS; Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
  • Schambach A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, USA.
  • Gerovska D; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain.
  • Araúzo-Bravo MJ; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
  • Vondran FWR; Department of General, Visceral and Transplant Surgery Regenerative Medicine and Experimental Surgery, Hannover Medical School, Hannover, Germany; German Center for Infection Research Partner Site Hannover-Braunschweig Hannover, Germany.
  • Cantz T; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Horscroft N; CureVac AG, Tübingen, Germany; Present address of NH, MRM Health NV Technologie park-Zwijnaarde 94, 9052 Gent, Belgium.
  • Balakrishnan A; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Chevessier F; CureVac AG, Tübingen, Germany.
  • Ott M; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Sharma AD; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Research Group Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany. Electronic address: sharma.amar@mh-hannover.de.
J Hepatol ; 75(6): 1420-1433, 2021 12.
Article en En | MEDLINE | ID: mdl-34453962
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factor Nuclear 4 del Hepatocito / Cirrosis Hepática Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factor Nuclear 4 del Hepatocito / Cirrosis Hepática Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article