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Towards in vivo photoacoustic imaging of vulnerable plaques in the carotid artery.
Muller, Jan-Willem; van Hees, Roy; van Sambeek, Marc; Boutouyrie, Pierre; Rutten, Marcel; Brands, Peter; Wu, Min; Lopata, Richard.
Afiliación
  • Muller JW; Photoacoustics and Ultrasound Laboratory Eindhoven (PULS/e), Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
  • van Hees R; Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands.
  • van Sambeek M; Photoacoustics and Ultrasound Laboratory Eindhoven (PULS/e), Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
  • Boutouyrie P; Photoacoustics and Ultrasound Laboratory Eindhoven (PULS/e), Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
  • Rutten M; Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands.
  • Brands P; Department of Pharmacology, Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
  • Wu M; Université de Paris, INSERM U970, Paris, France.
  • Lopata R; Cardiovascular Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Biomed Opt Express ; 12(7): 4207-4218, 2021 Jul 01.
Article en En | MEDLINE | ID: mdl-34457409
ABSTRACT
The main indicator for endarterectomy is the grade of stenosis, which results in severe overtreatment. Photoacoustic imaging (PAI) can provide patient-specific assessment of plaque morphology, and thereby vulnerability. A pilot study of PAI on carotid plaques in patients (n=16) was performed intraoperatively with a hand-held PAI system. By compensating for motion, the photoacoustic (PA) signal-to-noise ratio (SNR) could be increased by 5 dB in vivo. PA signals from hemorrhagic plaques had different characteristics compared to the signals from the carotid blood pool. This study is a key step towards a non-invasive application of PAI to detect vulnerable plaques.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos