Strontium mineralized silk fibroin porous microcarriers with enhanced osteogenesis as injectable bone tissue engineering vehicles.
Mater Sci Eng C Mater Biol Appl
; 128: 112354, 2021 Sep.
Article
en En
| MEDLINE
| ID: mdl-34474902
ABSTRACT
In this paper, silk fibroin (SF) porous microcarriers containing strontium were constructed as injectable bone tissue engineering vehicles. The effects of SF concentration and strontium content on micromorphology, element distribution, strontium ion release and cellular behavior of the constructed microcarriers were investigated. The microcarriers with an open interconnected pore can be fabricated by controlling the concentration of SF. The strontium functionalized SF microcarriers showed the sustained release of strontium ion and allowed bone mesenchymal stem cells (BMSCs) to attach, proliferate and secrete extracellular matrix. Furthermore, the strontium functionalized SF microcarriers improved the osteogenic capability of BMSCs in vitro compared with those microcarriers without sustained release of strontium ion. This study presents a valuable approach to fabricate polymeric microcarriers with the capability of sustained release of strontium ion that show potential in bone tissue engineering applications.
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1
Banco de datos:
MEDLINE
Asunto principal:
Fibroínas
Idioma:
En
Revista:
Mater Sci Eng C Mater Biol Appl
Año:
2021
Tipo del documento:
Article