Light-Driven Molecular Motors Boost the Selective Transport of Alkali Metal Ions through Phospholipid Bilayers.
J Am Chem Soc
; 143(38): 15653-15660, 2021 09 29.
Article
en En
| MEDLINE
| ID: mdl-34520204
ABSTRACT
A hydrophobic light-driven rotary motor is functionalized with two 18-crown-6 macrocycles and incorporated into phospholipid bilayers. In the presence of this molecular construct, fluorescence assays and patch clamp experiments show the formation of selective alkali ion channels through the membrane. Further, they reveal a strongly accelerated ion transport mechanism under light irradiation. This increase of the fractional ion transport activity (up to 400%) is attributed to the out-of-equilibrium actuation dynamics of the light-driven rotary motors, which help to overcome the activation energy necessary to achieve translocation of alkali ions between macrocycles along the artificial channels.
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Banco de datos:
MEDLINE
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En
Revista:
J Am Chem Soc
Año:
2021
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Article
País de afiliación:
Francia