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Distinctive Regulation of Emotional Behaviors and Fear-Related Gene Expression Responses in Two Extended Amygdala Subnuclei With Similar Molecular Profiles.
Ueda, Shuhei; Hosokawa, Masahito; Arikawa, Koji; Takahashi, Kiyofumi; Fujiwara, Mao; Kakita, Manami; Fukada, Taro; Koyama, Hiroaki; Horigane, Shin-Ichiro; Itoi, Keiichi; Kakeyama, Masaki; Matsunaga, Hiroko; Takeyama, Haruko; Bito, Haruhiko; Takemoto-Kimura, Sayaka.
Afiliación
  • Ueda S; Department of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Hosokawa M; Molecular/Cellular Neuroscience, Nagoya University Graduate School of Medicine, Nagoya University, Nagoya, Japan.
  • Arikawa K; Research Organization for Nano and Life Innovation, Waseda University, Tokyo, Japan.
  • Takahashi K; Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan.
  • Fujiwara M; Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Tokyo, Japan.
  • Kakita M; Research Organization for Nano and Life Innovation, Waseda University, Tokyo, Japan.
  • Fukada T; Research Organization for Nano and Life Innovation, Waseda University, Tokyo, Japan.
  • Koyama H; Department of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Horigane SI; Department of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Itoi K; Laboratory for Systems Neurosciences and Preventive Medicine, Faculty of Human Sciences, Waseda University, Tokorozawa, Japan.
  • Kakeyama M; Research Institute for Environmental Medical Sciences, Waseda University, Tokorozawa, Japan.
  • Matsunaga H; Department of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Takeyama H; Molecular/Cellular Neuroscience, Nagoya University Graduate School of Medicine, Nagoya University, Nagoya, Japan.
  • Bito H; Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Takemoto-Kimura S; Department of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Front Mol Neurosci ; 14: 741895, 2021.
Article en En | MEDLINE | ID: mdl-34539345
ABSTRACT
The central nucleus of the amygdala (CeA) and the lateral division of the bed nucleus of the stria terminalis (BNST) are the two major nuclei of the central extended amygdala that plays essential roles in threat processing, responsible for emotional states such as fear and anxiety. While some studies suggested functional differences between these nuclei, others showed anatomical and neurochemical similarities. Despite their complex subnuclear organization, subnuclei-specific functional impact on behavior and their underlying molecular profiles remain obscure. We here constitutively inhibited neurotransmission of protein kinase C-δ-positive (PKCδ+) neurons-a major cell type of the lateral subdivision of the CeA (CeL) and the oval nucleus of the BNST (BNSTov)-and found striking subnuclei-specific effects on fear- and anxiety-related behaviors, respectively. To obtain molecular clues for this dissociation, we conducted RNA sequencing in subnuclei-targeted micropunch samples. The CeL and the BNSTov displayed similar gene expression profiles at the basal level; however, both displayed differential gene expression when animals were exposed to fear-related stimuli, with a more robust expression change in the CeL. These findings provide novel insights into the molecular makeup and differential engagement of distinct subnuclei of the extended amygdala, critical for regulation of threat processing.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Front Mol Neurosci Año: 2021 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Front Mol Neurosci Año: 2021 Tipo del documento: Article País de afiliación: Japón