Differential adsorption of an analyte and its D4, D5 and 13C6 labeled analogues combined with instrument-specific carry-over issues: The Achilles' heel of ibrutinib TDM.

Mzik, Martin; Vánová, Nela; Kriegelstein, Michal; Hroch, Milos

Differential adsorption of an analyte and its D₄, D₅ and ¹³C₆ labeled analogues combined with instrument-specific carry-over issues: The Achilles' heel of ibrutinib TDM.

Mzik, Martin; Vánová, Nela; Kriegelstein, Michal; Hroch, Milos.

Afiliación

Mzik M; Department of Clinical Biochemistry and Diagnostics, University Hospital and Faculty of Medicine Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic.
Vánová N; Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
Kriegelstein M; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
Hroch M; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Zborovská 2089, 500 03 Hradec Králové, Czech Republic. Electronic address: hrochm@lfhk.cuni.cz.

J Pharm Biomed Anal ; 206: 114366, 2021 Nov 30.

Article en En | MEDLINE | ID: mdl-34555634

Asunto(s)

Espectrometría de Masas en Tándem; Adenina/análogos & derivados; Adsorción; Cromatografía Liquida; Piperidinas; Reproducibilidad de los Resultados

Palabras clave

Carry-over; Differential adsorption; Ibrutinib; Isotope dilution; Quantification; SIL-IS

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Espectrometría de Masas en Tándem Tipo de estudio: Guideline Idioma: En Revista: J Pharm Biomed Anal Año: 2021 Tipo del documento: Article País de afiliación: República Checa

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