Development and validation of a simple equation to evaluate dietary protein intake using the blood urea nitrogen/serum creatinine ratio in patients with stage 3 chronic kidney disease.
Int Urol Nephrol
; 54(6): 1279-1286, 2022 Jun.
Article
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| MEDLINE
| ID: mdl-34562197
ABSTRACT
PURPOSE:
The aim of this research was to develop a simple equation to evaluate dietary protein intake (DPI) in patients with stage 3 chronic kidney disease (CKD) using the blood urea nitrogen (BUN)/serum creatinine (SCr) ratio (BUN/SCr).METHODS:
In a prospective cohort of 136 inpatients with stage 3 CKD from 2 centres, the estimated dietary protein intake (DPI) was calculated using Maroni's formula after the patients implemented a 7 day protein-restricted diet. We developed estimation equations based on BUN/SCr and the spot urinary urea nitrogen (UUN)/urinary creatinine (UCr) ratio (UUN/UCr) in combination with sex and body mass index (BMI). These equations were then internally and externally validated.RESULTS:
The following candidate parameters were derived from univariate regression analysis for 5 established models sex, BMI, BUN/SCr, UUN and UUN/UCr. Sex and BMI were included in all models after variable evaluation using multiple regression analysis. UUN, UUN/UCr and BUN/SCr were included in model 3, model 4 and model 5, respectively. Both internal and external validation indicated that model 5 resulted in the lowest values for bias and root mean square error and the highest P30 compared with model 3 and model 4. Therefore, the model 5 equation, DPI = - 5.18 (- 14.49 if the patient is female) + 1.89 × BMI + 1.38 × BUN/SCr, was selected because of the higher correlation (r = 0.498) between the estimated DPI and predicted DPI.CONCLUSION:
The DPI equation developed using BUN/SCr, sex and BMI may be used to estimate protein intake for patients with stage 3 CKD. TRIAL REGISTRATION Chinese Clinical Trial Registry Center (ChiCTR-ROC-17011363). Registered on 11 May 2017, Retrospectively registered, http//www.chictr.org.cn/index.aspx .Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas en la Dieta
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Insuficiencia Renal Crónica
Tipo de estudio:
Observational_studies
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Prognostic_studies
Límite:
Female
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Humans
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Male
Idioma:
En
Revista:
Int Urol Nephrol
Año:
2022
Tipo del documento:
Article
País de afiliación:
China