Stress and the Role of the Gut-Brain Axis in the Pathogenesis of Schizophrenia: A Literature Review.
Int J Mol Sci
; 22(18)2021 Sep 09.
Article
en En
| MEDLINE
| ID: mdl-34575911
ABSTRACT
Schizophrenia is a severe neuropsychiatric disorder, and its etiology remains largely unknown. Environmental factors have been reported to play roles in the pathogenesis of schizophrenia, and one of the major environmental factors identified for this disorder is psychosocial stress. Several studies have suggested that stressful life events, as well as the chronic social stress associated with city life, may lead to the development of schizophrenia. The other factor is the gut-brain axis. The composition of the gut microbiome and alterations thereof may affect the brain and may lead to schizophrenia. The main interest of this review article is in overviewing the major recent findings on the effects of stress and the gut-brain axis, as well as their possible bidirectional effects, in the pathogenesis of schizophrenia.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Estrés Psicológico
/
Encéfalo
/
Retroalimentación Fisiológica
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Tracto Gastrointestinal
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Susceptibilidad a Enfermedades
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Systematic_reviews
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Mol Sci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Alemania