T Cell Epitope Prediction and Its Application to Immunotherapy.
Front Immunol
; 12: 712488, 2021.
Article
en En
| MEDLINE
| ID: mdl-34603286
ABSTRACT
T cells play a crucial role in controlling and driving the immune response with their ability to discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we focus on the currently available computational tools for epitope prediction, with a particular focus on tools aimed at identifying neoepitopes, i.e. cancer-specific peptides and their potential for use in immunotherapy for cancer treatment. This review will cover how these tools work, what kind of data they use, as well as pros and cons in their respective applications.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Redes Neurales de la Computación
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Epítopos de Linfocito T
/
Biología Computacional
/
Inmunoterapia
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Antígenos de Neoplasias
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Front Immunol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Dinamarca