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Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial.
Stephenson, Kathryn E; Julg, Boris; Tan, C Sabrina; Zash, Rebecca; Walsh, Stephen R; Rolle, Charlotte-Paige; Monczor, Ana N; Lupo, Sofia; Gelderblom, Huub C; Ansel, Jessica L; Kanjilal, Diane G; Maxfield, Lori F; Nkolola, Joseph; Borducchi, Erica N; Abbink, Peter; Liu, Jinyan; Peter, Lauren; Chandrashekar, Abishek; Nityanandam, Ramya; Lin, Zijin; Setaro, Alessandra; Sapiente, Joseph; Chen, Zhilin; Sunner, Lisa; Cassidy, Tyler; Bennett, Chelsey; Sato, Alicia; Mayer, Bryan; Perelson, Alan S; deCamp, Allan; Priddy, Frances H; Wagh, Kshitij; Giorgi, Elena E; Yates, Nicole L; Arduino, Roberto C; DeJesus, Edwin; Tomaras, Georgia D; Seaman, Michael S; Korber, Bette; Barouch, Dan H.
Afiliación
  • Stephenson KE; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Julg B; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Tan CS; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Zash R; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Walsh SR; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Rolle CP; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.
  • Monczor AN; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Lupo S; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Gelderblom HC; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Ansel JL; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Kanjilal DG; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Maxfield LF; Orlando Immunology Center, Orlando, FL, USA.
  • Nkolola J; McGovern Medical School at The University of Texas Health Science Center, Houston, TX, USA.
  • Borducchi EN; McGovern Medical School at The University of Texas Health Science Center, Houston, TX, USA.
  • Abbink P; International AIDS Vaccine Initiative, New York, NY, USA.
  • Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Peter L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Nityanandam R; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Lin Z; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Setaro A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Sapiente J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Chen Z; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Sunner L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Cassidy T; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Bennett C; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Sato A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Mayer B; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Perelson AS; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • deCamp A; International AIDS Vaccine Initiative, New York, NY, USA.
  • Priddy FH; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Wagh K; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Giorgi EE; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Yates NL; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Arduino RC; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, USA.
  • DeJesus E; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Tomaras GD; International AIDS Vaccine Initiative, New York, NY, USA.
  • Seaman MS; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Korber B; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Barouch DH; Duke Human Vaccine Institute, Duke University, Durham, NC, USA.
Nat Med ; 27(10): 1718-1724, 2021 10.
Article en En | MEDLINE | ID: mdl-34621054
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Infecciones por VIH / VIH-1 / Anticuerpos ampliamente neutralizantes Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Infecciones por VIH / VIH-1 / Anticuerpos ampliamente neutralizantes Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos