A cell-based drug discovery assay identifies inhibition of cell stress responses as a new approach to treatment of epidermolysis bullosa simplex.

Tan, Tong San; Common, John E A; Lim, John S Y; Badowski, Cedric; Firdaus, Muhammad Jasrie; Leonardi, Steven S; Lane, E Birgitte

Tan, Tong San; Common, John E A; Lim, John S Y; Badowski, Cedric; Firdaus, Muhammad Jasrie; Leonardi, Steven S; Lane, E Birgitte.

Afiliación

Tan TS; Skin Research Institute of Singapore, A*STAR, Immunos Building, 8A Biomedical Grove, Singapore138648.
Common JEA; Institute of Medical Biology, A*STAR, Immunos Building, 8A Biomedical Grove, Singapore138648.
Lim JSY; Skin Research Institute of Singapore, A*STAR, Immunos Building, 8A Biomedical Grove, Singapore138648.
Badowski C; Institute of Medical Biology, A*STAR, Immunos Building, 8A Biomedical Grove, Singapore138648.
Firdaus MJ; A*STAR Microscopy Platform, Immunos Building, 8A Biomedical Grove, Singapore138648.
Leonardi SS; Institute of Medical Biology, A*STAR, Immunos Building, 8A Biomedical Grove, Singapore138648.
Lane EB; Skin Research Institute of Singapore, A*STAR, Immunos Building, 8A Biomedical Grove, Singapore138648.

J Cell Sci ; 134(19)2021 10 01.

Article en En | MEDLINE | ID: mdl-34643242

Asunto(s)

Epidermólisis Ampollosa Simple; Citoesqueleto; Descubrimiento de Drogas; Epidermólisis Ampollosa Simple/tratamiento farmacológico; Epidermólisis Ampollosa Simple/genética; Humanos; Filamentos Intermedios; Queratinocitos; Queratinas/genética; Mutación/genética

Palabras clave

EBS; EGFR inhibitors; EGFR signalling; ERK1/2 signalling; Epidermolysis bullosa simplex; Keratin mutation; Pathway intervention therapy drug screen

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Epidermólisis Ampollosa Simple Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Cell Sci Año: 2021 Tipo del documento: Article

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