Oxysterol 7-&#945; Hydroxylase (CYP7B1) Attenuates Metabolic-Associated Fatty Liver Disease in Mice at Thermoneutrality.

Evangelakos, Ioannis; Schwinge, Dorothee; Worthmann, Anna; John, Clara; Roeder, Niklas; Pertzborn, Paul; Behrens, Janina; Schramm, Christoph; Scheja, Ludger; Heeren, Joerg

Oxysterol 7-α Hydroxylase (CYP7B1) Attenuates Metabolic-Associated Fatty Liver Disease in Mice at Thermoneutrality.

Evangelakos, Ioannis; Schwinge, Dorothee; Worthmann, Anna; John, Clara; Roeder, Niklas; Pertzborn, Paul; Behrens, Janina; Schramm, Christoph; Scheja, Ludger; Heeren, Joerg.

Afiliación

Evangelakos I; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Schwinge D; Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Worthmann A; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
John C; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Roeder N; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Pertzborn P; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Behrens J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Schramm C; Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Scheja L; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Heeren J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Cells ; 10(10)2021 10 05.

Article en En | MEDLINE | ID: mdl-34685636

Asunto(s)

Familia 7 del Citocromo P450/metabolismo; Hígado Graso/enzimología; Hígado Graso/metabolismo; Esteroide Hidroxilasas/metabolismo; Temperatura; Animales; Biomarcadores/metabolismo; Familia 7 del Citocromo P450/deficiencia; Inflamación/patología; Metabolismo de los Lípidos; Hígado/metabolismo; Hígado/patología; Cirrosis Hepática/metabolismo; Cirrosis Hepática/patología; Ratones; Ratones Noqueados; Fenotipo; Receptores de Lipoproteína/metabolismo; Bazo/inmunología; Esteroide Hidroxilasas/deficiencia; Regulación hacia Arriba

Palabras clave

Cyp7b1; T cells; bile acids; fibrosis; hydroxycholesterol; inflammation; metabolic-associated fatty liver disease; non-alcoholic fatty liver disease; oxysterol; steatohepatitis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esteroide Hidroxilasas / Temperatura / Hígado Graso / Familia 7 del Citocromo P450 Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Cells Año: 2021 Tipo del documento: Article País de afiliación: Alemania

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