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The protein 4.1R downregulates VEGFA in M2 macrophages to inhibit colon cancer metastasis.
Lu, Yu; Fan, Dandan; Wang, Wen; Gao, Xian; Li, Hanhan; Guo, Shuangshuang; Zhao, Luyang; Guo, Yaxin; Li, Bowen; Zhong, Yali; Zhang, Binglei; Liu, Jingjing; Dai, Liping; Kang, Qiaozhen; Ji, Zhenyu.
Afiliación
  • Lu Y; Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • Fan D; Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450052, Henan, China; BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052, Henan, China; Henan Key Laboratory for Pharmac
  • Wang W; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Gao X; Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • Li H; BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • Guo S; BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • Zhao L; BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • Guo Y; Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • Li B; Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • Zhong Y; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
  • Zhang B; Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • Liu J; Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450052, Henan, China; BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • Dai L; Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450052, Henan, China; BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • Kang Q; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, Henan, China. Electronic address: qzkang@zzu.edu.cn.
  • Ji Z; Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450052, Henan, China; BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052, Henan, China; Henan Key Laboratory for Pharmac
Exp Cell Res ; 409(1): 112896, 2021 12 01.
Article en En | MEDLINE | ID: mdl-34717920
M2 macrophages are crucial components of the tumour microenvironment and have been shown to be closely related to tumour progression. Co-culture with 4.1R-/- M2 macrophages enhances the malignancy of colon cancer (CC), but the mechanism remains unclear. Here, we report that protein 4.1R knockout reduced the phagocytosis of M2 macrophages (M-CSF/IL-4-treated bone marrow cells) and promoted MC38 colon cancer cell proliferation, migration, invasion, tumour formation and epithelial-mesenchymal transition (EMT), which are regulated by M2 macrophages. Further mechanistic dissection revealed that the 4.1R knockout upregulated vascular endothelial growth factor A (VEGFA) secreted by M2 macrophages and promoted colon cancer progression by activating the PI3K/AKT signalling pathway. In summary, our present study identified that 4.1R downregulates VEGFA secretion in M2 macrophages and delays the malignant potential of colon cancer by inhibiting the PI3K/AKT signalling pathway.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación hacia Abajo / Neoplasias del Colon / Factor A de Crecimiento Endotelial Vascular / Macrófagos / Proteínas de Microfilamentos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Cell Res Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación hacia Abajo / Neoplasias del Colon / Factor A de Crecimiento Endotelial Vascular / Macrófagos / Proteínas de Microfilamentos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Cell Res Año: 2021 Tipo del documento: Article País de afiliación: China