Your browser doesn't support javascript.
loading
Serological Biomarker Panel in Diagnosis of Atrophic Gastritis and Helicobacter pylori Infection in Gastroscopy Referral Patients: Clinical Validation of the New-Generation GastroPanel® Test.
Koivurova, Olli-Pekka; Koskela, Ritva; Blomster, Timo; Ala-Rämi, Antti; Lumme, Henri; Kettunen, Olli; Hukkanen, Janne; Karttunen, Tuomo J; Mäkinen, Markus; Ronkainen, Jukka; Syrjänen, Kari.
Afiliación
  • Koivurova OP; Departmernt of Endoscopy, Terveystalo Medical Center, Oulu, Finland.
  • Koskela R; Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.
  • Blomster T; Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.
  • Ala-Rämi A; Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.
  • Lumme H; Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.
  • Kettunen O; Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.
  • Hukkanen J; Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.
  • Karttunen TJ; Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland.
  • Mäkinen M; Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland.
  • Ronkainen J; Department of Pathology, Oulu University Hospital, Oulu, Finland.
  • Syrjänen K; Center for Life Course Health Research, University of Oulu, Oulu, Finland.
Anticancer Res ; 41(11): 5527-5537, 2021 Nov.
Article en En | MEDLINE | ID: mdl-34732423
BACKGROUND/AIM: Prompted by the increasing demand of non-invasive diagnostic tools for screening of gastric cancer (GC) risk conditions, i.e., atrophic gastritis (AG) and Helicobacter pylori (Hp) infection, the GastroPanel® test (GP: biomarker panel of PGI, PGII, G-17, Hp IgG ELISA) that was developed in the early 2000's, was recently updated to a new-generation (unified GP) test version. This clinical validation study evaluated the diagnostic accuracy of the new-generation GP test in detection of AG and Hp among gastroscopy referral patients in a University Clinic. PATIENTS AND METHODS: Altogether, 522 patients were enrolled among the patients referred for gastroscopy at the Gastro Center, Oulu University Hospital (OUH). All patients underwent gastroscopy with biopsies classified using the Updated Sydney System (USS), and blood sampling for GP testing. RESULTS: Biopsy-confirmed AG was found in 10.2% (53/511) of the patients. The overall agreement between the GP and the USS classification was 92.4% (95%CI=90.0-94.6%), with the weighted kappa (κw) of 0.861 (95%CI=0.834-0.883). In ROC analysis using moderate/severe AG of the corpus (AGC2+) as the endpoint, AUC=0.952 (95%CI=0.891-1.000) and AUC=0.998 (95%CI=0.996-1.000) for PGI and PGI/PGII, respectively. Hp IgG antibody ELISA detected biopsy-confirmed Hp-infection with AUC=0.993 (95%CI=0.987-0.999). CONCLUSION: The new generation GastroPanel® is a precise test for non-invasive diagnosis of atrophic gastritis and Hp-infection in dyspeptic patients referred for diagnostic gastroscopy.
Asunto(s)
Palabras clave

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Gastrinas / Pruebas Serológicas / Helicobacter pylori / Infecciones por Helicobacter / Gastroscopía / Pepsinógeno A / Pepsinógeno C / Gastritis Atrófica Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Anticancer Res Año: 2021 Tipo del documento: Article País de afiliación: Finlandia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Gastrinas / Pruebas Serológicas / Helicobacter pylori / Infecciones por Helicobacter / Gastroscopía / Pepsinógeno A / Pepsinógeno C / Gastritis Atrófica Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Anticancer Res Año: 2021 Tipo del documento: Article País de afiliación: Finlandia