Categorizing Sequences of Concern by Function To Better Assess Mechanisms of Microbial Pathogenesis.
Infect Immun
; 90(5): e0033421, 2022 05 19.
Article
en En
| MEDLINE
| ID: mdl-34780277
ABSTRACT
To identify sequences with a role in microbial pathogenesis, we assessed the adequacy of their annotation by existing controlled vocabularies and sequence databases. Our goal was to regularize descriptions of microbial pathogenesis for improved integration with bioinformatic applications. Here, we review the challenges of annotating sequences for pathogenic activity. We relate the categorization of more than 2,750 sequences of pathogenic microbes through a controlled vocabulary called Functions of Sequences of Concern (FunSoCs). These allow for an ease of description by both humans and machines. We provide a subset of 220 fully annotated sequences in the supplemental material as examples. The use of this compact (â¼30 terms), controlled vocabulary has potential benefits for research in microbial genomics, public health, biosecurity, biosurveillance, and the characterization of new and emerging pathogens.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vocabulario Controlado
/
Biología Computacional
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Infect Immun
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos