Better living through chemistry: CRISPR/Cas engineered T cells for cancer immunotherapy.
Curr Opin Immunol
; 74: 76-84, 2022 02.
Article
en En
| MEDLINE
| ID: mdl-34798542
ABSTRACT
T cells engineered to express transgenes such as chimeric antigen receptors (CAR) or modified T cell receptors (TCR) represent a new pillar of cancer therapy. Use of CRISPR/Cas gene-editing tools now allows even stronger and more precise control over the fate and function of engineered T cell therapies, including multiplex genome editing to facilitate use of off-the-shelf allogeneic T cells and novel approaches which have the potential to overcome some of the limitations of canonical Cas9-mediated DNA cleavage. This review summarizes the CRISPR/Cas techniques that have been used in preclinical research and outlines those that currently being tested in clinical trials.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sistemas CRISPR-Cas
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos