Lithium carbonate alleviates colon inflammation through modulating gut microbiota and Treg cells in a GPR43-dependent manner.

Huang, Shengjie; Hu, Shiping; Liu, Shuang; Tang, Bo; Liu, Yaojiang; Tang, Li; Lei, Yuanyuan; Zhong, Li; Yang, Shiming; He, Song

Huang, Shengjie; Hu, Shiping; Liu, Shuang; Tang, Bo; Liu, Yaojiang; Tang, Li; Lei, Yuanyuan; Zhong, Li; Yang, Shiming; He, Song.

Afiliación

Huang S; Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Hu S; Department of Gastroenterology, Third Military Medical University Second Affiliated Hospital, Chongqing, 400037, China.
Liu S; Department of Gastroenterology, Third Military Medical University Second Affiliated Hospital, Chongqing, 400037, China.
Tang B; Department of Gastroenterology, Third Military Medical University Second Affiliated Hospital, Chongqing, 400037, China.
Liu Y; Department of Gastroenterology, Third Military Medical University Second Affiliated Hospital, Chongqing, 400037, China.
Tang L; Department of Gastroenterology, Third Military Medical University Second Affiliated Hospital, Chongqing, 400037, China.
Lei Y; Department of Gastroenterology, Third Military Medical University Second Affiliated Hospital, Chongqing, 400037, China.
Zhong L; Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Yang S; Department of Gastroenterology, Third Military Medical University Second Affiliated Hospital, Chongqing, 400037, China. Electronic address: Yangshiming@tmmu.edu.cn.
He S; Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address: hedoctor65@cqmu.edu.cn.

Pharmacol Res ; 175: 105992, 2022 01.

Article en En | MEDLINE | ID: mdl-34801681

Asunto(s)

Antiinflamatorios/uso terapéutico; Colitis/tratamiento farmacológico; Microbioma Gastrointestinal/efectos de los fármacos; Carbonato de Litio/uso terapéutico; Receptores Acoplados a Proteínas G/genética; Linfocitos T Reguladores/efectos de los fármacos; Adulto; Anciano; Animales; Antiinflamatorios/farmacología; Colitis/inducido químicamente; Colitis/inmunología; Colitis/microbiología; Sulfato de Dextran; Trasplante de Microbiota Fecal; Femenino; Microbioma Gastrointestinal/genética; Humanos; Carbonato de Litio/farmacología; Masculino; Ratones Endogámicos C57BL; Ratones Noqueados; Persona de Mediana Edad; Linfocitos T Reguladores/inmunología

Palabras clave

Akkermansia muciniphila; Gut microbiota; Immune responses; Lithium carbonate; Short-chain fatty acids

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carbonato de Litio / Linfocitos T Reguladores / Colitis / Receptores Acoplados a Proteínas G / Microbioma Gastrointestinal / Antiinflamatorios Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China

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