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Understanding the genetics of intracranial aneurysms: A primer.
Laurent, Dimitri; Small, Coulter; Lucke-Wold, Brandon; Dodd, William S; Chalouhi, Nohra; Hu, Yin C; Hosaka, Koji; Motwani, Kartik; Martinez, Melanie; Polifka, Adam; Koch, Matthew; Busl, Katharina M; Maciel, Carolina B; Hoh, Brian.
Afiliación
  • Laurent D; Department of Neurosurgery, University of Florida, Gainesville, United States. Electronic address: Dimitri.Laurent@neurosurgery.ufl.edu.
  • Small C; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Lucke-Wold B; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Dodd WS; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Chalouhi N; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Hu YC; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Hosaka K; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Motwani K; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Martinez M; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Polifka A; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Koch M; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Busl KM; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Maciel CB; Department of Neurosurgery, University of Florida, Gainesville, United States.
  • Hoh B; Department of Neurosurgery, University of Florida, Gainesville, United States. Electronic address: Brian.Hoh@neurosurgery.ufl.edu.
Clin Neurol Neurosurg ; 212: 107060, 2022 01.
Article en En | MEDLINE | ID: mdl-34863053
ABSTRACT
The genetics of intracranial aneurysms is complex. Much work has been done looking at the extracellular matrix surrounding cerebral vasculature as well as the role of matrix metalloproteinases. This comprehensive review summarizes what is known to date about the important genetic components that predispose to aneurysm formation and critically discusses the published findings. We discuss promising pre-clinical models of aneurysm formation and subarachnoid hemorrhage, and highlight avenues for future discovery, while considering limitations in the research to date. This review will further serve as a comprehensive reference guide to understand the genetic underpinnings for aneurysm pathophysiology and act as a primer for further investigation.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aneurisma Intracraneal Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Clin Neurol Neurosurg Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aneurisma Intracraneal Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Clin Neurol Neurosurg Año: 2022 Tipo del documento: Article