When idiopathic male infertility is rooted in maternal malnutrition during the perinatal period in mice.
Biol Reprod
; 106(3): 463-476, 2022 03 19.
Article
en En
| MEDLINE
| ID: mdl-34875016
ABSTRACT
Infertility represents a growing burden worldwide, with one in seven couples presenting difficulties conceiving. Among these, 10-15% of the men have idiopathic infertility that does not correlate with any defect in the classical sperm parameters measured. In the present study, we used a mouse model to investigate the effects of maternal undernutrition on fertility in male progeny. Our results indicate that mothers fed on a low-protein diet during gestation and lactation produce male offspring with normal sperm morphology, concentration, and motility but exhibiting an overall decrease of fertility when they reach adulthood. Particularly, in contrast to control, sperm from these offspring show a remarkable lower capacity to fertilize oocytes when copulation occurs early in the estrus cycle relative to ovulation, due to an altered sperm capacitation. Our data demonstrate for the first time that maternal nutritional stress can have long-term consequences on the reproductive health of male progeny by affecting sperm physiology, especially capacitation, with no observable impact on spermatogenesis and classical quantitative and qualitative sperm parameters. Moreover, our experimental model could be of major interest to study, explain, and ultimately treat certain categories of infertilities.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Desnutrición
/
Infertilidad Masculina
Tipo de estudio:
Etiology_studies
/
Qualitative_research
Límite:
Adult
/
Animals
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Revista:
Biol Reprod
Año:
2022
Tipo del documento:
Article
País de afiliación:
Francia