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A clinical decision support system is associated with reduced loss to follow-up among patients receiving HIV treatment in Kenya: a cluster randomized trial.
Oluoch, Tom; Cornet, Ronald; Muthusi, Jacques; Katana, Abraham; Kimanga, Davies; Kwaro, Daniel; Okeyo, Nicky; Abu-Hanna, Ameen; de Keizer, Nicolette.
Afiliación
  • Oluoch T; Division of Global HIV and TB, US Centers for Disease Control and Prevention, 1600 Clifton Road NE, GA, 30329, Atlanta, USA. toluoch@cdc.gov.
  • Cornet R; Department of Medical Informatics, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
  • Muthusi J; Division of Global HIV and TB, US Centers for Disease Control and Prevention, Nairobi, Kenya.
  • Katana A; Division of Global HIV and TB, US Centers for Disease Control and Prevention, Nairobi, Kenya.
  • Kimanga D; Division of Global HIV and TB, US Centers for Disease Control and Prevention, Nairobi, Kenya.
  • Kwaro D; Kenya Medical Research Institute - CDC Collaborative Program, Kisumu, Kenya.
  • Okeyo N; Kenya Medical Research Institute - CDC Collaborative Program, Kisumu, Kenya.
  • Abu-Hanna A; Department of Medical Informatics, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
  • de Keizer N; Department of Medical Informatics, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
BMC Med Inform Decis Mak ; 21(1): 357, 2021 12 20.
Article en En | MEDLINE | ID: mdl-34930228
ABSTRACT

BACKGROUND:

Loss to follow-up (LFTU) among HIV patients remains a major obstacle to achieving treatment goals with the risk of failure to achieve viral suppression and thereby increased HIV transmission. Although use of clinical decision support systems (CDSS) has been shown to improve adherence to HIV clinical guidance, to our knowledge, this is among the first studies conducted to show its effect on LTFU in low-resource settings.

METHODS:

We analyzed data from a cluster randomized controlled trial in adults and children (aged ≥ 18 months) who were receiving antiretroviral therapy at 20 HIV clinics in western Kenya between Sept 1, 2012 and Jan 31, 2014. Participating clinics were randomly assigned, via block randomization. Clinics in the control arm had electronic health records (EHR) only while the intervention arm had an EHR with CDSS. The study objectives were to assess the effects of a CDSS, implemented as alerts on an EHR system, on (1) the proportion of patients that were LTFU, (2) LTFU patients traced and successfully linked back to treatment, and (3) time from enrollment on the study to documentation of LTFU.

RESULTS:

Among 5901 eligible patients receiving ART, 40.6% (n = 2396) were LTFU during the study period. CDSS was associated with lower LTFU among the patients (Adjusted Odds Ratio-aOR 0.70 (95% CI 0.65-0.77)). The proportions of patients linked back to treatment were 25.8% (95% CI 21.5-25.0) and 30.6% (95% CI 27.9-33.4)) in EHR only and EHR with CDSS sites respectively. CDSS was marginally associated with reduced time from enrollment on the study to first documentation of LTFU (adjusted Hazard Ratio-aHR 0.85 (95% CI 0.78-0.92)).

CONCLUSION:

A CDSS can potentially improve quality of care through reduction and early detection of defaulting and LTFU among HIV patients and their re-engagement in care in a resource-limited country. Future research is needed on how CDSS can best be combined with other interventions to reduce LTFU. Trial registration NCT01634802. Registered at www.clinicaltrials.gov on 12-Jul-2012. Registered prospectively.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Fármacos Anti-VIH / Sistemas de Apoyo a Decisiones Clínicas Tipo de estudio: Clinical_trials / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Child / Humans País/Región como asunto: Africa Idioma: En Revista: BMC Med Inform Decis Mak Asunto de la revista: INFORMATICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Fármacos Anti-VIH / Sistemas de Apoyo a Decisiones Clínicas Tipo de estudio: Clinical_trials / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Child / Humans País/Región como asunto: Africa Idioma: En Revista: BMC Med Inform Decis Mak Asunto de la revista: INFORMATICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos