Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216.

Cotton, Thomas R; Cobbold, Simon A; Bernardini, Jonathan P; Richardson, Lachlan W; Wang, Xiangyi S; Lechtenberg, Bernhard C

Cotton, Thomas R; Cobbold, Simon A; Bernardini, Jonathan P; Richardson, Lachlan W; Wang, Xiangyi S; Lechtenberg, Bernhard C.

Afiliación

Cotton TR; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.
Cobbold SA; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.
Bernardini JP; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.
Richardson LW; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.
Wang XS; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.
Lechtenberg BC; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: lechtenberg.b@wehi.edu.au.

Mol Cell ; 82(3): 598-615.e8, 2022 02 03.

Article en En | MEDLINE | ID: mdl-34998453

Asunto(s)

Ataxia Cerebelosa/enzimología; Hormona Liberadora de Gonadotropina/deficiencia; Hipogonadismo/enzimología; Procesamiento Proteico-Postraduccional; Ubiquitina-Proteína Ligasas/metabolismo; Regulación Alostérica; Sitios de Unión; Catálisis; Ataxia Cerebelosa/genética; Cristalografía por Rayos X; Predisposición Genética a la Enfermedad; Hormona Liberadora de Gonadotropina/genética; Células HEK293; Humanos; Hipogonadismo/genética; Mutación con Pérdida de Función; Lisina; Modelos Moleculares; Fenotipo; Fosforilación; Unión Proteica; Conformación Proteica; Relación Estructura-Actividad; Ubiquitina-Proteína Ligasas/genética; Ubiquitinación

Palabras clave

E3 ligases; Gordon-Holmes syndrome; RBR; RNF216; allostery; neurodegeneration; phosphorylation; structural biology; ubiquitin; zinc finger

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ataxia Cerebelosa / Procesamiento Proteico-Postraduccional / Hormona Liberadora de Gonadotropina / Ubiquitina-Proteína Ligasas / Hipogonadismo Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Australia

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