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Deciphering the High Viscosity of a Therapeutic Monoclonal Antibody in High Concentration Formulations by Microdialysis-Hydrogen/Deuterium Exchange Mass Spectrometry.
Xu, Xiaobin; Zhang, Aming; Xu, Yingjie; Cao, Yuan; Cale, Stephen; Franklin, Matthew; Sarangapani, Prasad; Ihnat, Peter M; Qiu, Haibo; Liu, Dingjiang; Pyles, Erica A; Shameem, Mohammed; Li, Ning.
Afiliación
  • Xu X; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: xiaobin.xu@regeneron.com.
  • Zhang A; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Xu Y; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Cao Y; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Cale S; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Franklin M; Structural Biology, Regeneron Pharmaceutical, Inc., Tarrytown, NY 10591, USA.
  • Sarangapani P; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Ihnat PM; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Qiu H; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: haibo.qiu@regeneron.com.
  • Liu D; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Pyles EA; Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Shameem M; Formulation Development, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Li N; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
J Pharm Sci ; 111(5): 1335-1345, 2022 05.
Article en En | MEDLINE | ID: mdl-34999091
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Medición de Intercambio de Deuterio / Espectrometría de Masas de Intercambio de Hidrógeno-Deuterio Límite: Humans Idioma: En Revista: J Pharm Sci Año: 2022 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Medición de Intercambio de Deuterio / Espectrometría de Masas de Intercambio de Hidrógeno-Deuterio Límite: Humans Idioma: En Revista: J Pharm Sci Año: 2022 Tipo del documento: Article