Alterins, a new family of marine antibacterial cyclolipopeptides.
Int J Antimicrob Agents
; 59(3): 106514, 2022 Mar.
Article
en En
| MEDLINE
| ID: mdl-34999240
ABSTRACT
Five strains of Pseudoalteromonas, isolated from oyster haemolymph, have exhibited antibacterial activity against several Gram-negative bacteria. Bioactive compounds have been identified in their cell-free supernatant and characterised as alterins, which are cyclolipopeptides comprising a heptapeptidic ring connected to a fatty acid chain. Using ultra-performance liquid chromatography-high-resolution mass spectrometry, this paper describes 37 structural analogues differing from each other by one or more amino acid residue, the length of the fatty acid chain, its hydroxylation and the presence of unsaturation.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pseudoalteromonas
/
Bacterias Gramnegativas
Idioma:
En
Revista:
Int J Antimicrob Agents
Año:
2022
Tipo del documento:
Article
País de afiliación:
Francia