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Incidence of Arterial Hypertension in People With Periodontitis and Characterization of the Oral and Subgingival Microbiome: A Study Protocol.
Martínez-García, Mireya; Castrejón-Pérez, Roberto Carlos; Rodríguez-Hernández, Adriana Patricia; Sandoval-Motta, Santiago; Vallejo, Maite; Borges-Yáñez, Socorro Aída; Hernández-Lemus, Enrique.
Afiliación
  • Martínez-García M; Sociomedical Research Unit, Instituto Nacional de Cardiología Ignacio Chávez, México City, Mexico.
  • Castrejón-Pérez RC; Department of Clinical and Epidemiological Geriatric Research, Instituto Nacional de Geriatría, México City, Mexico.
  • Rodríguez-Hernández AP; Laboratory of Molecular Genetics, Graduate Studies and Research Division, School of Dentistry, Universidad Nacional Autónoma de México, México City, Mexico.
  • Sandoval-Motta S; Computational Genomics Division, Instituto Nacional de Medicina Genómica, México City, Mexico.
  • Vallejo M; Cátedras CONACYT Consejo Nacional de Ciencia y Tecnología, México City, Mexico.
  • Borges-Yáñez SA; Center for Complexity Sciences, Universidad Nacional Autónoma de México, México City, Mexico.
  • Hernández-Lemus E; Sociomedical Research Unit, Instituto Nacional de Cardiología Ignacio Chávez, México City, Mexico.
Front Cardiovasc Med ; 8: 763293, 2021.
Article en En | MEDLINE | ID: mdl-35071346
ABSTRACT
Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. High blood pressure in particular, continues to increase throughout the global population at an increasingly fast pace. The relationship between arterial hypertension and periodontitis has been recently discussed in the context of its origins and implications. Particularly relevant is the role of the periodontal microbiome linked to persistent local and systemic inflammation, along with other risk factors and social determinants of health. The present protocol will investigate/assess the association between periodontal disease and its microbiome on the onset of hypertension, within a cohort from Mexico City. One thousand two hundred twelve participants will be studied during a 60-month period. Studies will include analysis of periodontal conditions, sampling and sequencing of the salivary and subgingival microbiome, interviews on nutritional and lifestyle habits, social determinants of health, blood pressure and anthropometric measurements. Statistical associations and several classic epidemiology and machine learning approaches will be performed to analyze the data. Implications for the generation of public policy-by early public health interventions or epidemiological surveillance approaches-and for the population empowerment-via the establishment of primary prevention recommendations, highlighting the relationship between oral and cardiovascular health-will be considered. This latter set of interventions will be supported by a carefully planned science communication and health promotion strategy. This study has been registered and approved by the Research and Ethics Committee of the School of Dentistry, Universidad Nacional Autónoma de México (CIE/0308/05/2019) and the National Institute of Genomic Medicine (CEI/2020/12). The umbrella cohort was approved by the Institutional Bioethics Committee of the National Institute of Cardiology-Ignacio Chavez (INC-ICh) under code 13-802.
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Incidence_studies / Risk_factors_studies Idioma: En Revista: Front Cardiovasc Med Año: 2021 Tipo del documento: Article País de afiliación: México

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Incidence_studies / Risk_factors_studies Idioma: En Revista: Front Cardiovasc Med Año: 2021 Tipo del documento: Article País de afiliación: México