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Discovery of novel potent covalent inhibitor-based EGFR degrader with excellent in vivo efficacy.
Shi, Shi; Du, Yu; Huang, Lei; Cui, Jiaqi; Niu, Jing; Xu, Yungen; Zhu, Qihua.
Afiliación
  • Shi S; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Du Y; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
  • Huang L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Cui J; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
  • Niu J; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Xu Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China. Electronic address: xyg@cpu.edu.cn.
  • Zhu Q; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China. Electronic address: zhuqihua@vip.126.com.
Bioorg Chem ; 120: 105605, 2022 03.
Article en En | MEDLINE | ID: mdl-35081479
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2022 Tipo del documento: Article País de afiliación: China