Febuxostat and its major acyl glucuronide metabolite are potent inhibitors of organic anion transporter 3: Implications for drug-drug interactions with rivaroxaban.

Tang, Lloyd Wei Tat; Cheong, Tino Woon Huai; Chan, Eric Chun Yong

Tang, Lloyd Wei Tat; Cheong, Tino Woon Huai; Chan, Eric Chun Yong.

Afiliación

Tang LWT; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Cheong TWH; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Chan ECY; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.

Biopharm Drug Dispos ; 43(2): 57-65, 2022 Apr.

Article en En | MEDLINE | ID: mdl-35088420

Asunto(s)

Glucurónidos; Rivaroxabán; Interacciones Farmacológicas; Febuxostat/farmacología; Células HEK293; Humanos; Proteína 1 de Transporte de Anión Orgánico/metabolismo; Transportadores de Anión Orgánico Sodio-Independiente/metabolismo; Rivaroxabán/farmacología

Palabras clave

drug-drug interactions; febuxostat; organic anion transporter 3; rivaroxaban; static modelling

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glucurónidos / Rivaroxabán Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biopharm Drug Dispos Año: 2022 Tipo del documento: Article País de afiliación: Singapur

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