Neuroimaging of Dopamine Transporter Density in the Striatum of Disordered Gamblers.
J Gambl Stud
; 39(1): 119-136, 2023 Mar.
Article
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| MEDLINE
| ID: mdl-35099670
ABSTRACT
The aim of the present research was to add to the growing literature on dopamine and gambling disorder (GD) by assessing whether GD is associated with dopamine transporter (DAT) density in the ventral striatum compared to healthy controls and whether DAT density was associated with key characteristics of GD (e.g., abstinence, craving). In a cross-sectional investigation using single-photon emission computed tomography with a technetium-99m-labeled tropane derivative as a radiotracer with SPECT imaging, fifteen participants with GD and 15 controls (non-gambling individuals, matched for age, gender, handedness, and smoking status) were measured. The GD group completed self-reported questionnaires regarding gambling. Striatal DAT density did not differ between the two groups. Conversely, striatal DAT density correlated significantly with various measures of recent gambling, but not with measures of chronic gambling. Multivariate analysis, adjusted for age and smoking status, showed that DAT density in the left striatum correlated positively with time spent gambling and gambling craving in the last month, whereas DAT density in the right striatum correlated negatively with abstinence self-efficacy. The results suggests that DAT density in the striatum is associated with recent gambling activity and gambling expectation.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Dopamina a través de la Membrana Plasmática
/
Juego de Azar
Límite:
Humans
Idioma:
En
Revista:
J Gambl Stud
Asunto de la revista:
PSICOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Brasil