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Sea grapes extract improves blood glucose, total cholesterol, and PGC-1α in rats fed on cholesterol- and fat-enriched diet.
Kuswari, Mury; Nurkolis, Fahrul; Mayulu, Nelly; Ibrahim, Faisal Maulana; Taslim, Nurpudji Astuti; Wewengkang, Defny Silvia; Sabrina, Nindy; Arifin, Ghafur Rasyid; Mantik, Keren Esther Kristina; Bahar, Muhammad Rahimi; Rifqiyati, Najda; Rompies, Ronald; Augusta, Piko Satria; Permatasari, Happy Kurnia.
Afiliación
  • Kuswari M; Nutrition, Universitas Esa Unggul, Jakarta, Jakarta, 11510, Indonesia.
  • Nurkolis F; Biological Sciences, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga Yogyakarta), Yogyakarta, Yogyakarta, 55281, Indonesia.
  • Mayulu N; Nutrition, Sam Ratulangi University, Manado, North Sulawesi, 95115, Indonesia.
  • Ibrahim FM; Pharmaceutical Analysis and Medicinal Chemistry, Universitas Padjajaran, Sumedang, West Java, 45363, Indonesia.
  • Taslim NA; Nutritional Sciences, Hasanuddin University, Makassar, South Sulawesi, 90245, Indonesia.
  • Wewengkang DS; Pharmacy, Sam Ratulangi University, Manado, North Sulawesi, 95115, Indonesia.
  • Sabrina N; Nutrition, Sahid University of Jakarta, South Jakarta, Jakarta, 12870, Indonesia.
  • Arifin GR; Medicine, University of Indonesia, Depok, West Java, 16424, Indonesia.
  • Mantik KEK; Nutrition, Sam Ratulangi University, Manado, North Sulawesi, 95115, Indonesia.
  • Bahar MR; Pediatrics, Sam Ratulangi University, Manado, North Sulawesi, 95115, Indonesia.
  • Rifqiyati N; Biological Sciences, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga Yogyakarta), Yogyakarta, Yogyakarta, 55281, Indonesia.
  • Rompies R; Pediatrics, Sam Ratulangi University, Manado, North Sulawesi, 95115, Indonesia.
  • Augusta PS; Medicine, Brawijaya University, Malang, East Java, 65145, Indonesia.
  • Permatasari HK; Medicine, Brawijaya University, Malang, East Java, 65145, Indonesia.
F1000Res ; 10: 718, 2021.
Article en En | MEDLINE | ID: mdl-35136575
Background: Sea grapes or  Caulerpa racemosa have a lot of phytochemical content, especially unsaturated fatty acids that are beneficial for health. This study aims to evaluate the effects of sea grapes extract on blood glucose levels, total cholesterol-, and Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1α in male Wistar rats, which were given per-oral (p.o.) cholesterol- and carbohydrates fat-enriched diets (CFED). Methods: Forty male Wistar albino rats weighing between 200 - 250 g were used for this study. Animals were randomly distributed into four groups of ten animals each. Group A served as control (received standard dry pellet diet). Rats in group B were fed on CFED for 4 weeks.  Groups C and D were fed on CFED and were administered 150 and 450 mg/kg of  sea grapes extract (p.o.), respectively. Results: Group C rats indicated a blood glucose reduction and an increase in PGC-1α serum, in comparison to group D (p<0.05). There were no significant differences between group C and D in blood cholesterol reduction (high dose of the extract did not have significant effects) (p=0.222), and both groups had the same effect in lowering total cholesterol in rats.  Conclusion: Sea grapes extract is proven to improve blood glucose, total cholesterol, and PGC-1α levels in rats fed with CFED.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glucemia / Vitis Límite: Animals Idioma: En Revista: F1000Res Año: 2021 Tipo del documento: Article País de afiliación: Indonesia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glucemia / Vitis Límite: Animals Idioma: En Revista: F1000Res Año: 2021 Tipo del documento: Article País de afiliación: Indonesia