The mouse resource at National Resource Center for Mutant Mice.
Mamm Genome
; 33(1): 143-156, 2022 03.
Article
en En
| MEDLINE
| ID: mdl-35138443
ABSTRACT
Mouse models are essential for dissecting disease mechanisms and defining potential drug targets. There are more than 18,500 mouse strains available for research communities in National Resource Center for Mutant Mice (NRCMM) of China, affiliated with Model Animal Research Center of Nanjing University and Gempharmatech Company. In 2019, Gempharmatech launched the Knockout All Project (KOAP) aiming to generate null mutants and gene floxed strains for all protein-coding genes in mouse genome within 5 years. So far, KOAP has generated 8,004 floxed strains and 9,769 KO (knockout) strains (updated to Oct, 2021). NRCMM also created hundreds of Cre transgenic lines, mutant knock-in models, immuno-deficient models, and humanized mouse models. As a member of the international mouse phenotyping consortium (IMPC), NRCMM provides comprehensive phenotyping services for mouse models. In summary, NRCMM will continue to support biomedical community with new mouse models as well as related services.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Genoma
Límite:
Animals
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Mamm Genome
Asunto de la revista:
GENETICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
China